Selected publications:

 

Hutten S#, Chen JX, Isaacs AM, Dormann D#. Poly-GR Impairs PRMT1-Mediated Arginine Methylation of Disease-Linked RNA-Binding Proteins by Acting as a Substrate Sink. Biochemistry. 2024 Sep 3;63(17):2141-2152. doi: 10.1021/acs.biochem.4c00308.

 

Dormann D#, Lemke EA#. Adding intrinsically disordered proteins to biological ageing clocks.

Nat Cell Biol. 2024 Jun;26(6):851-858. doi: 10.1038/s41556-024-01423-w.

 

Zambusi A*, Novoselc KT*, Hutten S, Kalpazidou S, Koupourtidou C, Schieweck R, Aschenbroich S, Gruijs da Silva L, Yazgili AS, Schmid B, Delbridge C, Sirko S, Günes ZI, Liebscher S, Schlegel J, Aliee H, Theis F, Meiners S, Kiebler M, Dormann D* and Ninkovic J*#. TDP-43 condensates regulate the reactivity of microglia after traumatic brain injury, Nat Neurosci 2022, Dec;25(12):1608-1625.

 

Gruijs da Silva LA, Simonetti F, Hutten S, Riemenschneider H, Sternburg EL, Pietrek LM, Gebel J, Doetsch V, Edbauer D, Hummer G, Stelzl LS, Dormann D#. Disease-linked TDP-43 hyperphosphorylation suppresses TDP-43 condensation and aggregation; EMBO J 2022, Apr 19;41(8):e108443.

 

Sternburg EL, Gruijs da Silva LA, Dormann D#. Post-translational modifications on RNA-binding proteins: accelerators, brakes, or passengers in neurodegeneration? Trends Biochem Sci. 2022 Jan;47(1):6-22.                                                                                                             

Baade I*, Hutten S*, Sternburg EL, Pörschke M, Hofweber M, Dormann D#, Kehlenbach RH#. The RNA-binding protein FUS is chaperoned and imported into the nucleus by a network of import receptors, J Biol Chem. 2021 Jan-Jun;296:100659.           

 

Hutten S#, Usluer S., Bourgeois B., Simonetti F., Odeh H.M., Fare CM, Czuppa M, Hruska-Plochan M, Hofweber M, Polymenidou M, Shorter J, Edbauer D, Madl T, Dormann D#. Nuclear import receptors directly bind to arginine-rich dipeptide repeat proteins and suppress their pathological interactions, Cell Reports, 2020 Dec 22; 33(12):108538

 

Bourgeois B*, Hutten S*, Gottschalk B, Hofweber M, Richter M, Sternat J, Abou-Ajram C, Göbl C, Leitinger G, Graier W, Dormann D#, and Madl T#. Non-classical nuclear localization signals mediate nuclear import of CIRBP, PNAS 2020 Apr 14;117(15):8503-8514. doi: 10.1073/pnas.1918944117.

 

Alberti S#, Dormann D#. Liquid liquid phase separation and disease. Annu Rev Genet 2019, Dec 3;53:171-194           

 

Ederle H, Funk C, Abou-Ajram C, Hutten S, Funk EBE, Kehlenbach R, Bailer S, Dormann D#. Nuclear egress of TDP-43 and FUS occurs independently of Exportin-1/CRM1, Scientific Reports 2018 May 4;8(1):7084

 

Hofweber M*, Hutten S*, Bourgeois B, Spreitzer E, Niedner-Boblenz A, Schifferer M, Ruepp MD, Simons M, Niessing D, Madl T, Dormann D#. Phase separation of FUS is suppressed by its nuclear import receptor and arginine methylation. Cell 2018 Apr 19;173(3):706-719.e13

 

Dormann D#, Madl T, Valori CF, Bentmann E, Tahirovic S, Abou-Ajram C, Kremmer E, Ansorge O, Mackenzie IR, Neumann M, Haass C#. Arginine methylation next to the PY-NLS modulates Transportin binding and nuclear import of FUS. EMBO J. 2012 Nov 14;31(22):4258-75.

 

Dormann D, Rodde R, Edbauer D, Bentmann E, Fischer I, Hruscha A, Than ME, Mackenzie IR, Capell A, Schmid B, Neumann M, Haass C. ALS-associated fused in sarcoma (FUS) mutations disrupt Transportin-mediated nuclear transport. EMBO J. 2010 Aug 18;29(16):2841-57.

 

* = equal contribution; # = corresponding author

 

 

Link to complete publication list:

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Note: Before 2007 Dormann D = Schmid D